Difference in the effectiveness of subthalamic nucleus and globus pallidus deep brain stimulation in Parkinson’s disease

Deep brain stimulation (DBS) is regarded as a feasible Parkinson’s disease (PD) treatment option. The subthalamic nucleus (STN) and globus pallidus (GPi) are the two most common sites for DBS. following criteria were used to select studies that examined Unified PD Rating Scale (UPDRS) III: (1) had at least three months of follow-up; (2) compared both GPi STN-DBS; (3) each group included five individuals; (4) conducted after 2010. majority found no statistically significant difference in UPDRS score improvements between groups. Although there some encouraging findings terms action tremor, rigidity, urinary symptoms, indicating STN-DBS would be better alternative, appeared side effects; nonetheless, it cannot said superior. Other larger randomized clinical trials with longer follow-up periods control groups required determine which target more effective has fewer negative effects on patients. Keywords: stimulation, pallidus, disease, nucleus,